Regulation of intestinal epithelial intercellular adhesion and barrier function by desmosomal cadherin desmocollin-2-Reference-Cited by-同舟云学术

Regulation of intestinal epithelial intercellular adhesion and barrier function by desmosomal cadherin desmocollin-2

Published:2021-04-15 Issue:8 Volume:32 Page:753-768
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Raya-Sandino Arturo¹,Luissint Anny-Claude¹,Kusters Dennis H. M.¹,Narayanan Vani²,Flemming Sven¹,Garcia-Hernandez Vicky¹,Godsel Lisa M.³,Green Kathleen J.³⁴,Hagen Susan J.⁵,Conway Daniel E.²,Parkos Charles A.¹,Nusrat Asma¹

Affiliation:

1. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109

2. Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284

3. Departments of Pathology and Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611

4. Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611

5. Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02115

Abstract

Our findings emphasize a major role for Dsc2 in the regulation of barrier function using inducible Dsc2 depletion in murine intestinal epithelial cells in vivo. Functional analysis revealed that loss of Dsc2 resulted in decreased intercellular adhesion and increased intestinal permeability associated with higher tension on desmosomes.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference73 articles.

1. Mammalian Diaphanous 1 Mediates a Pathway for E-cadherin to Stabilize Epithelial Barriers through Junctional Contractility

2. Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis

3. GSK3- and PRMT-1–dependent modifications of desmoplakin control desmoplakin–cytoskeleton dynamics

4. Cytokine Tuning of Intestinal Epithelial Function

5. Nesprin-2G, a Component of the Nuclear LINC Complex, Is Subject to Myosin-Dependent Tension

Cited by 26 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Duodenal organoids from metabolic dysfunction-associated steatohepatitis patients exhibit altered digestive homeostasis;2024-07-03

2. Dsg2 truncation causes a lethal barrier breakdown in mice;2024-07-03

3. The centrosomal protein FGFR1OP controls myosin function in murine intestinal epithelial cells;Developmental Cell;2024-06

4. Microbial Signatures in COVID-19: Distinguishing Mild and Severe Disease via Gut Microbiota;Biomedicines;2024-05-01

5. Experimentally validated oxidative stress -associated prognostic signatures describe the immune landscape and predict the drug response and prognosis of SKCM;Frontiers in Immunology;2024-04-10