Praja1 ubiquitin ligase facilitates degradation of polyglutamine proteins and suppresses polyglutamine-mediated toxicity-Reference-Cited by-同舟云学术

Praja1 ubiquitin ligase facilitates degradation of polyglutamine proteins and suppresses polyglutamine-mediated toxicity

Published:2021-08-15 Issue:17 Volume:32 Page:1579-1593
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Ghosh Baijayanti¹,Karmakar Susnata²,Prasad Mohit²,Mandal Atin K.¹

Affiliation:

1. Division of Molecular Medicine, Bose Institute, Kolkata 700054, India

2. Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, Nadia 741246, West Bengal, India

Abstract

Accumulation of intracellular toxic misfolded proteins acts as an important pathological hallmark in polyglutamine (polyQ) diseases. In this study, we investigate how Praja1 ubiquitin ligase, which is abundantly expressed in the brain, clears these polyQ proteins and subsequently helps in suppressing the cytotoxicity associated with them.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference70 articles.

1. Impairment of the Ubiquitin-Proteasome System by Protein Aggregation

2. Global Impairment of the Ubiquitin-Proteasome System by Nuclear or Cytoplasmic Protein Aggregates Precedes Inclusion Body Formation

3. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

4. A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease

5. Evidence for Proteasome Involvement in Polyglutamine Disease: Localization to Nuclear Inclusions in SCA3/MJD and Suppression of Polyglutamine Aggregation in vitro

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