Loss of TDP-43 mediates severe neurotoxicity by suppressing PJA1 gene transcription in the monkey brain-Reference-Cited by-同舟云学术

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Loss of TDP-43 mediates severe neurotoxicity by suppressing PJA1 gene transcription in the monkey brain

Published:2024-01-09 Issue:1 Volume:81 Page:
ISSN:1420-682X
Container-title:Cellular and Molecular Life Sciences
language:en
Short-container-title:Cell. Mol. Life Sci.

Author:

Zhu Longhong,Deng Fuyu,Bai Dazhang,Hou Junqi,Jia Qingqing,Zhang Chen,Ou Kaili,Li Shihua,Li Xiao-Jiang,Yin Peng^ORCID

Funder

National Natural Science Foundation of China

Guangdong Basic and Applied Basic Research

Department of Science and Technology of Guangdong Province

Guangzhou Key Research Program on Brain Science

Fundamental Research Funds for the Central Universities

Publisher

Springer Science and Business Media LLC

Link

https://link.springer.com/content/pdf/10.1007/s00018-023-05066-2.pdf

Reference80 articles.

1. Chen-Plotkin AS, Lee VM-Y, Trojanowski JQ (2010) TAR DNA-binding protein 43 in neurodegenerative disease. Nat Rev Neurol 6:211–220

2. Lee EB, Lee VM-Y, Trojanowski JQ (2012) Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration. Nat Rev Neurosci 13:38–50

3. Guo L, Shorter J (2017) Biology and pathobiology of TDP-43 and emergent therapeutic strategies. Cold Spring Harb Perspect Med 7:a024554

4. Polymenidou M, Lagier-Tourenne C, Hutt KR, Huelga SC, Moran J, Liang TY, Ling S-C, Sun E, Wancewicz E, Mazur C (2011) Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Nat Neurosci 14:459–468

5. Cohen TJ, Lee VM, Trojanowski JQ (2011) TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies. Trends Mol Med 17:659–667

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