Yeast pericentrin/Spc110 contains multiple domains required for tethering the γ-tubulin complex to the centrosome-Reference-Cited by-同舟云学术

Yeast pericentrin/Spc110 contains multiple domains required for tethering the γ-tubulin complex to the centrosome

Published:2020-07-01 Issue:14 Volume:31 Page:1437-1452
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Alonso Annabel¹,Fabritius Amy¹,Ozzello Courtney²,Andreas Mike³,Klenchin Dima⁴,Rayment Ivan⁵,Winey Mark¹

Affiliation:

1. Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616

2. The Boulder Laboratory for 3D Electron Microscopy of Cells, Department of Molecular, Cellular, and Developmental Biology, University of Colorado–Boulder, Boulder, CO 80309

3. Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109

4. Department of Pathology and Laboratory Medicine, University of Wisconsin–Madison, Madison, WI 53706

5. Department of Biochemistry, University of Wisconsin–Madison, Madison, WI 53706

Abstract

A domain of a yeast centrosome component is found to be toxic when overexpressed. The finding is used to find interaction determinants with binding partners at the centrosome. The mechanism of toxicity involves displacement of the wild-type protein from the centrosome and is informative about aberrations in centrosomes seen in transformed cells.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference70 articles.

1. Localization of Core Spindle Pole Body (SPB) Components during SPB Duplication in Saccharomyces cerevisiae

2. Structure and duplication of the centrosome

3. The Centrosome in Cells and Organisms

4. Saccharomyces cerevisiaeCells with Defective Spindle Pole Body Outer Plaques Accomplish Nuclear Migration via Half-Bridge–organized Microtubules

5. Duplication of Spindle Plaques and Integration of the Yeast Cell Cycle

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