Computer simulation of the wound process (review of literature)

Abstract

Relevance. Computer simulation is a mathematical modeling process performed on a computer that is designed to predict the behavior or results of a real or physical system. Computer simulation has a number of advantages over classical models of animal experiments: the cheapness of the method (the need to acquire and maintain animals disappears by itself), the speed of obtaining results, the absence of bioethical problems, the ability to change the conditions of the experiment, etc.he purpose of this study is to review the methods of computer simulation of the wound process, to identify the shortcomings of the models and propose ways to solve them, as well as to select the best existing model for describing wound regeneration.Material and methods. In the course of this work, an analysis was made of foreign and domestic literature on the problem of computer modeling of the wound process.Results. After analyzing the relevant literature on this topic, the problem is seen precisely in the insufficiently studied process of wound regeneration, since many different cells, cytokines, growth factors, enzymes, fibrillar proteins, etc. take part in it. The models that currently exist describe wound regeneration only in an extremely generalized way, which does not allow us to apply them in clinical situations. Analyzing literature sources, we came to the conclusion that both numerical approaches, both cellular-biochemical (the first type of models) and phenomenological (the second type) are applicable in the case of wound modeling and can be used very successfully. The problem is that on the basis of one approach it is impossible to display a complete picture of wound healing, in this way it is possible to predict only individual regeneration parameters necessary for certain purposes due to the complexity and versatility of this typical pathophysiological process.Conclusion. Computer modeling of wounds is still a controversial and complex topic. Existing models are not intended to describe all the processes occurring in a healing wound. It is much more productive to describe the various phenomena during healing separately. This is due to the fact that many elements are involved in the regeneration of the skin, which are almost impossible to take into account in full. The available models are of exclusively scientific value, consisting in attempts to understand all complex processes and interactions. Practical application is difficult, since existing models require specific input data that require highly specialized equipment. If we abstract from all this, then the best existing model of the first type is the model of the authors Yangyang Wang, Christian F. Guerrero-Juarez, Yuchi Qiu and co-authors, in addition to it, any of the described phenomenological models will do.