Prognostic value of connective tissue dysplasia in children with urinary tract infection

Abstract

Research purpose. To determine the frequency and severity of connective tissue dysplasia in children with urinary tract infection to predict the course of the disease and justify the scope of the survey.Characteristics of children and research methods. A prospective study was conducted during 5 years, which included 120 children with community-acquired urinary tract infection at the age of 1 to 17 years. There were 90 children with acute pyelonephritis and 30 patients with acute cystitis. All children underwent a clinical and instrumental examination with a study of the manifestations of connective tissue dysplasia and assessment of its severity.Results. Connective tissue dysplasia occurred in 30% of children with urinary tract infection and depended on the form and course of pyelonephritis. With secondary pyelonephritis, its frequency increased to 56% with a predominance of the first degree of severity. When prospectively observed, only in 2 out of 30 girls with acute cystitis, the disease took a chronic course; one of them was diagnosed with connective tissue dysplasia of the I degree of severity. A relapse-free course of pyelonephritis was observed in 54 (68%) children. In 25 (32%) patients with secondary pyelonephritis, the course of the disease was recurring; in this group, connective tissue dysplasia was significantly more frequent and was observed in 23 (92%) of 25 patients.Conclusion. If seven to ten external signs of connective tissue dysplasia are detected in children with pyelonephritis, it is necessary to examine not only the urinary system, but also other systems for complex treatment.