Clinical and functional features of chronic pyelonephritis in children with connective tissue dysplasia-Reference-Cited by-同舟云学术

Clinical and functional features of chronic pyelonephritis in children with connective tissue dysplasia

Published:2022-11-27 Issue:4 Volume:13 Page:53-63
ISSN:2587-6252
Container-title:Pediatrician (St. Petersburg)
language:
Short-container-title:Pediatr (SPb)

Author:

Ivanova Irina I.,Koval Natalia Yu.

Abstract

BACKGROUND: There is information in the literature about the effect of connective tissue dysplasia (СTD) on the course of many somatic diseases. The role of СTD in the development of chronic pyelonephritis (СhPN) is presented differently to different authors, which is why it became necessary to conduct this study. AIM: The aim of the work is to evaluate the effect of СTD on the course and manifestations of chronic secondary pyelonephritis in children. MATERIALS AND METHODS: 142 children from 6 to 17 years old with СhPN were examined. They were divided into 2 groups: the 1st group included 108 children with manifestations of СTD, including 41 people with СTD of the 3rd degree and 67 people with СTD of the 2nd degree; group 2 34 patients without СTD. The groups were comparable in gender and age. The examination was carried out according to the standards for patients with ChPN. Signs of СTD were evaluated by the method of T.I. Kadurina. RESULTS: Obstructive and mixed variants of СhPN are typical for children with СTD. In most patients, the disease manifested at 12 years of life; at school age the first signs of the disease occurred mainly in children without СTD with dysmetabolic disorders. Relapses of СhPN in children with СTD occurred 1.5 times more often during the year and 2,1 times more often during 5 years of follow-up. Patients with СTD are characterized by a wider range of pathogens, anemia, a high incidence of structural abnormalities and urodynamic disorders, a tendency to form foci of nephrosclerosis. The need for surgical treatment in the presence of СTD increases in patients with СhPN by 4.6 times, including in repeated and radical operations. In children with grade 3 СTD, all these signs are more represented. CONCLUSIONS: СTD affects the course and manifestations of СhPN in children, creating an unfavorable background. It seems promising to study the role of СTD in the occurrence of anemia in children with СhPN.

Publisher

ECO-Vector LLC

Subject

General Medicine

Reference23 articles.

1. Vereshchagina GN. Pochki pri sistemnoi displazii soedinitel’noi tkani. Medical news of the North Caucasus. 2008;(2):87–89. (In Russ.)

2. V’yushkova NV. Khronicheskii pielonefrit u lits molodogo vozrasta s displaziei soedinitel’noi tkani: kliniko-morfologicheskie osobennosti [dissertation abstract]. Omsk, 2010. 22 p. (In Russ.)

3. Ivanova II, Gnusaev SF, Koval’ NYu. Osobennosti techeniya boleznei mochevydelitel’noi sistemy u detei s displaziei soedinitel’noi tkani. The Russian Pediatric Journal. 2012;(4):32–35. (In Russ.)

4. Ivanova II, Gnusaev SF, Koval’ NYu. Khronicheskii vtorichnyi pielonefrit i nedifferentsirovannaya displaziya soedinitel’noi tkani u detei. Proceeding of the V Russian forum with international participation “Pediatriya Sankt-Peterburga: opyt, innovatsii, dostizheniya”. Saint Petersburg, 2013. P. 69–76. (In Russ.)

5. Ivanova YuV. Klinicheskie i fenotipicheskie osobennosti detei s pielonefritom pri puzyrno-mochetochnikovom reflyukse [dissertation abstract]. Moscow, 2005. 28 p. (In Russ.)