Exploring the Potential to Extend Productive Lifespan in Nondiabetics through Maintaining Optimal Insulin Sensitivity: Amelioration of an Abated Version of the Metabolic Syndrome

Abstract

Objectives: An inadequate metabolic response on the part of blood glucose to the usual or even augmented circulating levels of insulin is broadly referred to as “insulin resistance” (IR). IR has been associated with developing a collection of biological perturbations recognized as metabolic syndrome, a less-than-optimal IR status with aging is prevalent worldwide in the modern nondiabetic population due mainly to current poor nutritional practices. Material and Methods: This phenomenon is explored using two different surrogates representing the strength of IR (serum fasting blood glucose and the ratio triglycerides/high-density lipoprotein cholesterol) as well as two different means to gage aging (chronological age and declining glomerular filtration rate over the lifespan). Results: Establishing an important role in general health for what seem to be trivial but persistent stages of IR in the eyes of most observers today is important since it would provide early incentives to develop safe, convenient preventive measures to slow the aging process and lengthen meaningful lifespan. Conclusion: Ultimately, the objective is to maintain the body in optimal shape by reducing IR throughout aging. This may help mitigate all sorts of metabolic disorders, including infectious processes occurring in one’s lifetime.