Phage Infection Restores PQS Signaling and Enhances Growth of a Pseudomonas aeruginosa <i>lasI</i> Quorum-Sensing Mutant-Reference-Cited by-同舟云学术

Phage Infection Restores PQS Signaling and Enhances Growth of a Pseudomonas aeruginosa lasI Quorum-Sensing Mutant

Published:2022-05-17 Issue:5 Volume:204 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Høyland-Kroghsbo Nina Molin¹^ORCID,Bassler Bonnie L.¹²^ORCID

Affiliation:

1. Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA

2. Howard Hughes Medical Institute, Chevy Chase, Maryland, USA

Abstract

Clinical isolates of P. aeruginosa frequently harbor mutations in particular QS genes. Here, we show that infection by select temperate phages restores QS, a cell-to-cell communication mechanism in a P. aeruginosa QS mutant.

Funder

HHS | National Institutes of Health

Howard Hughes Medical Institute

Lundbeckfonden

National Science Foundation

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.00557-21

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4. LasR of Pseudomonas aeruginosa is a transcriptional activator of the alkaline protease gene (apr) and an enhancer of exotoxin A expression

5. Multiple homologues of LuxR and LuxI control expression of virulence determinants and secondary metabolites through quorum sensing in Pseudomonas aeruginosa PAO1

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