Mucosal Administration of Flagellin Induces Innate Immunity in the Mouse Lung-Reference-Cited by-同舟云学术

Mucosal Administration of Flagellin Induces Innate Immunity in the Mouse Lung

Published:2004-11 Issue:11 Volume:72 Page:6676-6679
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Honko Anna N.¹,Mizel Steven B.¹

Affiliation:

1. Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, North Carolina

Abstract

ABSTRACT Nonsurgical intratracheal instillation of 1 μg of purified, recombinant flagellin in several strains of mice stimulated a transient innate immune response in the lung characterized by the infiltration of neutrophils and the rapid production of tumor necrosis factor alpha, interleukin 6, granulocyte colony-stimulating factor, and the chemokines keratinocyte-derived chemokine, MIP1α, and MIP-2.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.72.11.6676-6679.2004

Reference29 articles.

1. Intranasal Administration of Synthetic Recombinant Peptide-Based Vaccine Protects Mice from Infection by Schistosoma mansoni

2. Flagella of Salmonella typhimurium are a virulence factor in infected C57BL/6J mice

3. Salmonella Flagellin Induces Tumor Necrosis Factor Alpha in a Human Promonocytic Cell Line

4. Salmonellae activate tumor necrosis factor alpha production in a human promonocytic cell line via a released polypeptide

5. Induction of Cytokine Synthesis by Flagella from Gram-Negative Bacteria May Be Dependent on the Activation or Differentiation State of Human Monocytes

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