Activity of the Fluoroquinolone DC-159a in the Initial and Continuation Phases of Treatment of Murine Tuberculosis-Reference-Cited by-同舟云学术

Activity of the Fluoroquinolone DC-159a in the Initial and Continuation Phases of Treatment of Murine Tuberculosis

Published:2011-01-31 Issue:4 Volume:55 Page:1781-1783
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob. Agents Chemother.

Author:

Ahmad Zahoor,Minkowski Austin,Peloquin Charles A.,Williams Kathy N.,Mdluli Khisimuzi E.,Grosset Jacques H.,Nuermberger Eric L.

Abstract

ABSTRACTDC-159a is a new fluoroquinolone with more potentin vitroactivity than available fluoroquinolones against both drug-susceptible and fluoroquinolone-resistantMycobacterium tuberculosis. Here, we report that DC-159a displays pharmacokinetics similar to those of moxifloxacin yet is more active than moxifloxacin during both the initial and continuation phases of treatment in a murine model. These results warrant further preclinical evaluation of DC-159a in selected drug combinations against drug-susceptible and fluoroquinolone-resistant tuberculosis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference13 articles.

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