Affiliation:
1. Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan
Abstract
ABSTRACT
The
in vitro
activities of DC-159a against seven species of
Mycobacterium
were compared with moxifloxacin, gatifloxacin, levofloxacin, and rifampin. DC-159a was the most active compound against quinolone-resistant multidrug-resistant
M. tuberculosis
(MIC
90
, 0.5 μg/ml) as well as drug-susceptible isolates (MIC
90
, 0.06 μg/ml). The anti-tubercle bacilli activity of DC-159a was 4- to 32-fold more potent than those of currently available quinolones. DC-159a also demonstrated the highest activities against clinically important nontuberculous mycobacteria.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
44 articles.
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