Plasmid-Mediated Aminoglycoside Phosphotransferase of Broad Substrate Range That Phosphorylates Amikacin-Reference-Cited by-同舟云学术

Plasmid-Mediated Aminoglycoside Phosphotransferase of Broad Substrate Range That Phosphorylates Amikacin

Published:1977-04 Issue:4 Volume:11 Page:619-624
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Courvalin Patrice¹,Davies Julian¹

Affiliation:

1. Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706

Abstract

A plasmid-mediated aminoglycoside phosphotransferase that phosphorylates amikacin has been detected in clinical isolates of Staphylococcus aureus . This enzyme does not confer detectable amikacin resistance to the strains.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.11.4.619

Reference10 articles.

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2. Mechanisms of antibiotic resistance in bacteria. Annu;Benveniste R.;Rev. Biochem.,1973

3. Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate;Biddlecombe S.;Antimicrob. Agents Chemother.,1976

4. Enzymes that inactivate antibiotics in transit to their targets;Davies J. E.;Ann. N. Y. Acad. Sci.,1974

5. Haas M. and J. E. Dowding. 1975. Aminoglycosidemodifying enzymes p. 611-628. In J. H. Hash (ed.) Methods in enzymology vol. 43. Academic Press Inc. New York.

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