Apralogs: Apramycin 5-O-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltransferase (3)-IV Resistance Determinant

Author:

Quirke Jonathan C. K.1234,Rajasekaran Parasuraman134,Sarpe Vikram A.134,Sonousi Amr4,Osinnii Ivan5,Gysin Marina5,Haldimann Klara5,Fang Qiao-Jun6,Shcherbakov Dimitri5,Hobbie Sven N.5,Sha Su-Hua6,Schacht Jochen7,Vasella Andrea8,Böttger Erik C.5,Crich David1234ORCID

Affiliation:

1. Department of Pharmaceutical and Biomedical Sciences, University of Georgia, 250 West Green Street, Athens, Georgia 30602, United States

2. Department of Chemistry, University of Georgia, 140 Cedar Street, Athens, Georgia 30602, United States

3. Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, Georgia 30602, United States

4. Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, United States

5. Institute of Medical Microbiology, University of Zurich, Gloriastrasse 28, 8006 Zürich, Switzerland

6. Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Walton Research Building, Room 403-E, 39 Sabin Street, Charleston, South Carolina 29425, United States

7. Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109, United States

8. Organic Chemistry Laboratory, ETH Zürich, Vladimir-Prelog-Weg 1-5/10, 8093 Zürich, Switzerland

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Reference98 articles.

1. Ose, E. E. Treatment of swine dysentery with apramycin. U.S. Patent 3,876,767, 1975.

2. Aminoglycosides and Aminocyclitols

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