Genital antibody response to a parenteral gonococcal pilus vaccine-Reference-Cited by-同舟云学术

Genital antibody response to a parenteral gonococcal pilus vaccine

Published:1982-06 Issue:3 Volume:36 Page:1006-1012
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

McChesney D,Tramont E C,Boslego J W,Ciak J,Sadoff J,Brinton C C

Abstract

A parenteral gonococcal pilus vaccine which has previously been shown to be safe and antigenic also results in the production of specific local genital antibody. All three major antibody classes were present in the local secretions, but immunoglobulin A predominated, a portion of which is dimeric 11S immunoglobulin A. This mucosal antibody is also capable of blocking the attachment of gonococci to epithelial cells. The antibody cross-reacted with five heterologous pili in a solid-phase radioimmunoassay. These results are encouraging and suggest that a gonococcal pilus vaccine may be efficacious in preventing gonorrhea.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.36.3.1006-1012.1982

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