Novel Bacterial Topoisomerase Inhibitor Gepotidacin Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats-Reference-Cited by-同舟云学术

Novel Bacterial Topoisomerase Inhibitor Gepotidacin Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats

Published:2022-11-15 Issue:11 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Fishman Cindy¹^ORCID,Caverly Rae Jessica M.¹,Posobiec Lorraine M.¹,Laffan Susan B.¹,Lerman Steven A.¹,Pearson Neil²,Janmohamed Salim³,Dumont Etienne⁴,Nunn-Floyd Deatra¹,Stanislaus Dinesh J.¹

Affiliation:

1. Nonclinical Safety, GSK Research and Development, Collegeville, Pennsylvania, USA

2. Medicinal Chemistry, GSK Research and Development, Collegeville, Pennsylvania, USA

3. Clinical Sciences, GSK Research and Development, Brentford, Middlesex, United Kingdom

4. Clinical Sciences, GSK Research and Development, Collegeville, Pennsylvania, USA

Abstract

Fluoroquinolone use in children is limited due to its potential toxicity and negative effects on skeletal development, but the actual effects/risks of fluoroquinolones on bone growth and the mechanisms behind fluoroquinolone-driven arthropathy remain unknown. Gepotidacin is a novel, bactericidal, first-in-class triazaacenaphthylene antibiotic with a unique mechanism of action that is not anticipated to have the same risks to bone growth as those of fluoroquinolones.

Funder

GSK

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00483-22

Reference46 articles.

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4. Histologic and Histochemical Changes in Articular Cartilages of Immature Beagle Dogs Dosed with Difloxacin, a Fluoroquinolone

5. Toxicokinetic study of norfloxacin-induced arthropathy in juvenile animals

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3. Novel Bacterial Topoisomerase Inhibitor Gepotidacin Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats;Antimicrobial Agents and Chemotherapy;2022-11-15