Author:
Horita Yasuhiro,Takii Takemasa,Yagi Tetsuya,Ogawa Kenji,Fujiwara Nagatoshi,Inagaki Emi,Kremer Laurent,Sato Yasuo,Kuroishi Ryuji,Lee YooSa,Makino Toshiaki,Mizukami Hajime,Hasegawa Tomohiro,Yamamoto Ryuji,Onozaki Kikuo
Abstract
ABSTRACTThe antimycobacterial activities of disulfiram (DSF) and diethyldithiocarbamate (DDC) against multidrug- and extensively drug-resistant tuberculosis (MDR/XDR-TB) clinical isolates were evaluatedin vitro. Both DSF and DDC exhibited potent antitubercular activities against 42 clinical isolates ofM. tuberculosis, including MDR/XDR-TB strains. Moreover, DSF showed remarkable bactericidal activityex vivoandin vivo. Therefore, DSF might be a drug repurposed for the treatment of MDR/XDR-TB.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
55 articles.
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