Applications and Opportunities in Using Disulfides, Thiosulfinates, and Thiosulfonates as Antibacterials

Author:

Blume Lindsay1,Long Timothy E.2,Turos Edward1

Affiliation:

1. Department of Chemistry, University of South Florida, Tampa, FL 33620, USA

2. Department of Pharmaceutical Sciences, Marshall University, Huntington, WV 25755, USA

Abstract

Sulfur-containing molecules have a long history of bioactivity, especially as antibacterial agents in the fight against infectious pathogens. Organosulfur compounds from natural products have been used to treat infections throughout history. Many commercially available antibiotics also have sulfur-based moieties in their structural backbones. In the following review, we summarize sulfur-containing antibacterial compounds, focusing on disulfides, thiosulfinates, and thiosulfonates, and opportunities for future developments in the field.

Funder

National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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