Sialic Acid Binding Sites in VP2 of Bluetongue Virus and Their Use during Virus Entry-Reference-Cited by-同舟云学术

Sialic Acid Binding Sites in VP2 of Bluetongue Virus and Their Use during Virus Entry

Published:2022-01-12 Issue:1 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Wu Weining¹,Roy Polly¹^ORCID

Affiliation:

1. Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

Abstract

To date no receptor has been assigned for non-enveloped bluetongue virus. To determine if the outermost spike-like VP2 protein is responsible for host cell attachment via interaction with sialic acids, we first generated a protein-based VP2-nanoparticle, for the multivalent presentation of recombinant VP2 protein.

Funder

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01677-21

Reference26 articles.

1. Atomic model of a nonenveloped virus reveals pH sensors for a coordinated process of cell entry

2. Conformation of the VP2 protein of bluetongue virus (BTV) determines the involvement in virus neutralization of highly conserved epitopes within the BTV serogroup

3. Bluetongue Virus Entry into Cells