Affiliation:
1. Centro de Investigación en Sanidad Animal (CISA-INIA/CSIC), Valdeolmos, 28130 Madrid, Spain
Abstract
Epizootic Hemorrhagic Disease (EHD) of ruminants is a viral pathology that has significant welfare, social, and economic implications. The causative agent, epizootic hemorrhagic disease virus (EHDV), belongs to the Orbivirus genus and leads to significant regional disease outbreaks among livestock and wildlife in North America, Asia, Africa, and Oceania, causing significant morbidity and mortality. During the past decade, this viral disease has become a real threat for countries of the Mediterranean basin, with the recent occurrence of several important outbreaks in livestock. Moreover, the European Union registered the first cases of EHDV ever detected within its territory. Competent vectors involved in viral transmission, Culicoides midges, are expanding its distribution, conceivably due to global climate change. Therefore, livestock and wild ruminants around the globe are at risk for this serious disease. This review provides an overview of current knowledge about EHDV, including changes of distribution and virulence, an examination of different animal models of disease, and a discussion about potential treatments to control the disease.
Subject
Virology,Microbiology (medical),Microbiology
Reference180 articles.
1. The Nucleic Acid and Proteins of Epizootic Haemorrhagic Disease Virus;Huismans;Onderstepoort J. Vet. Res.,1979
2. Characterization of a Second Open Reading Frame in Genome Segment 10 of Bluetongue Virus;Stewart;J. Gen. Virol.,2015
3. Belhouchet, M., Mohd Jaafar, F., Firth, A.E., Grimes, J.M., Mertens, P.P.C., and Attoui, H. (2011). Detection of a Fourth Orbivirus Non-Structural Protein. PLoS ONE, 6.
4. Protein Coding Assignment for the Genome of Epizootic Haemorrhagic Disease Virus;Mecham;J. Gen. Virol.,1988
5. Bluetongue Virus Coat Protein VP2 Contains Sialic Acid-Binding Domains, and VP5 Resembles Enveloped Virus Fusion Proteins;Zhang;Proc. Natl. Acad. Sci. USA,2010
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