Pharmacokinetics of Oral Doxycycline during Combination Treatment of Severe Falciparum Malaria-Reference-Cited by-同舟云学术

Pharmacokinetics of Oral Doxycycline during Combination Treatment of Severe Falciparum Malaria

Published:2005-04 Issue:4 Volume:49 Page:1622-1625
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Newton Paul N.¹²,Chaulet Jean-François³,Brockman Alan⁴¹,Chierakul Wirongrong¹,Dondorp Arjen¹²,Ruangveerayuth Ronatrai⁵,Looareesuwan Sornchai¹,Mounier Cyril³,White Nicholas J.⁴¹²

Affiliation:

1. Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

2. Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom

3. Laboratoire de biochimie, toxicologie et pharmacologie, Hopital d'Instruction des Armées Desgenettes, Lyon, France

4. Shoklo Malaria Research Unit

5. Mae Sot Hospital, Mae Sot, Tak

Abstract

ABSTRACT The pharmacokinetics of oral doxycycline administered at 200 mg every 24 h were investigated in 17 patients recovering from severe Plasmodium falciparum malaria. The data suggest that the doses of doxycycline currently recommended (circa 3.5 mg/kg of body weight daily) may not be optimal.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.4.1622-1625.2005

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