Glibenclamide, a Blocker of K + ATP Channels, Shows Antileishmanial Activity in Experimental Murine Cutaneous Leishmaniasis-Reference-Cited by-同舟云学术

Glibenclamide, a Blocker of K + ATP Channels, Shows Antileishmanial Activity in Experimental Murine Cutaneous Leishmaniasis

Published:2006-12 Issue:12 Volume:50 Page:4214-4216
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Serrano-Martín Xenón¹,Payares Gilberto²,Mendoza-León Alexis¹

Affiliation:

1. Laboratorio de Bioquímica y Biología Molecular de Parásitos

2. Laboratorio de Inmunología y Quimioterapia, Instituto de Biología Experimental (IBE), Facultad de Ciencias, Universidad Central de Venezuela, Apartado 47577, Caracas 1041A, Venezuela

Abstract

ABSTRACT Glibenclamide reduced the rate of lesion growth in BALB/c mice infected with Leishmania ( Leishmania ) mexicana , the effect was dose dependent, and the highest dose proved more effective than glucantime. Cross-resistance to glucantime was found in animals infected with a glibenclamide-resistant line, but combined therapy reduced lesion progression even in the glibenclamide-resistant strain.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00617-06

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