Complex Class 1 Integron Carrying qnrB62 and bla VIM-2 in a Citrobacter freundii Clinical Isolate-Reference-Cited by-同舟云学术

Complex Class 1 Integron Carrying qnrB62 and bla VIM-2 in a Citrobacter freundii Clinical Isolate

Published:2016-11 Issue:11 Volume:60 Page:6937-6940
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lee Jae Jin¹,Kim Mi-Na²,Park Kwang Seung¹,Lee Jung Hun¹,Karim Asad Mustafa¹,Park Moonhee¹³,Kim Ji Hwan¹,Lee Sang Hee¹

Affiliation:

1. National Leading Research Laboratory of Drug Resistance Proteomics, Department of Biological Sciences, Myongji University, Yongin, Gyeonggido, Republic of Korea

2. Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea

3. DNA Analysis Division, Seoul Institute, National Forensic Service, Yangcheongu, Seoul, Republic of Korea

Abstract

ABSTRACT The coexistence of qnrB62 and bla VIM-2 was detected in a Citrobacter clinical isolate. The reduced fluoroquinolone susceptibility is attributable to qnrB62 , mutations of quinolone-resistance-determining regions, and an efflux pump or pumps. The genetic context surrounding chromosomal qnrB62 was a novel complex class 1 integron (In1184::IS CR1 :: qnrB62 ) containing a unique gene array ( bla VIM-2 - aacA4′-8 - gucD ). An 18-nucleotide deletion at the 3′ end of the pspA gene [ pspA (Δ 18 )], upstream of qnrB62 , and an inverted repeat region (IRR2) were detected in In1184::IS CR1 :: qnrB62 , indicating past transposition events.

Funder

NRF

MOF

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00614-16

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