The KQ Element, a Complex Genetic Region Conferring Transferable Resistance to Carbapenems, Aminoglycosides, and Fluoroquinolones in Klebsiella pneumoniae-Reference-Cited by-同舟云学术

The KQ Element, a Complex Genetic Region Conferring Transferable Resistance to Carbapenems, Aminoglycosides, and Fluoroquinolones in Klebsiella pneumoniae

Published:2008-09 Issue:9 Volume:52 Page:3427-3429
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Rice Louis B.¹²,Carias Lenore L.¹,Hutton Rebecca A.²,Rudin Susan D.¹,Endimiani Andrea¹,Bonomo Robert A.¹²

Affiliation:

1. Medical and Research Services, Louis Stokes Cleveland VA Medical Center

2. Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio

Abstract

ABSTRACT The bla KPC-3 and qnrB19 determinants of transferable Klebsiella pneumoniae plasmid pLRM24 reside within a complex region consisting of a Tn 1331 backbone into which a Tn 4401 -like element and qnrB19 mobilized by an adjacent IS Ecp1 insertion sequence have been inserted. This novel element represents a coalescence of genes conferring multidrug resistance in K. pneumoniae .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00493-08

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