Fungicidal activity of tioconazole in relation to growth phase of Candida albicans and Candida parapsilosis

Author:

Beggs W H

Abstract

It was shown that tioconazole possesses an important property not shared by ketoconazole and miconazole, its well-known relatives in the imidazole group of antifungal drugs. At a concentration of 3.8 X 10(-5) M, tioconazole, like miconazole, caused rapid 2- to 3-log reductions in CFU per milliliter when added to late-logarithmic-phase Candida albicans or Candida parapsilosis cells. Only tioconazole, however, exerted similar reductions when added to diluted stationary-phase cultures. This growth-phase-independent lethal action has important clinical implications and may explain the superior performance of tioconazole, which was observed in earlier comparative drug studies.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference15 articles.

1. Physiological states of Candida parapsilosis in relation to miconazole and ketoconazole susceptibilities;Beggs W. H.;IRCS Med. Sci. Libr. Compend.,1983

2. Comparison of miconazole- and ketoconazole-induced release of K+ from Candida species;Beggs W. H.;J. Antimicrob. Chemother.,1983

3. The effect of antifungal imidazoles on resting cells of Candida parapsilosis;Beggs W. H.;IRCS Med. Sci. Libr. Compend.,1983

4. Growth phase in relation to ketoconazole and miconazole susceptibilities of Candida albicans;Beggs W. H.;Antimicrob. Agents Chemother.,1984

5. Mode of action of miconazole on Candida albicans: effect on growth, viability and K+ release;Cope J. E.;J. Gen. Microbiol.,1980

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