Enterococcus faecium Clade Competition in the Presence of β-Lactam Antibiotics in a Mouse GI Tract Colonization Model-Reference-Cited by-同舟云学术

Enterococcus faecium Clade Competition in the Presence of β-Lactam Antibiotics in a Mouse GI Tract Colonization Model

Published:2022-11-15 Issue:11 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Singh Kavindra V.¹²^ORCID,Montealegre Maria Camila¹²^ORCID,Murray Barbara E.¹²³^ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA

2. UTHealth Center for Antimicrobial Resistance and Microbial Genomics (CARMiG), Houston, Texas, USA

3. Department of Microbiology and Molecular Genetics, University of Texas Medical, Houston, Texas, USA

Abstract

Previously, we showed that Enterococcus faecium clade B strains outcompeted health care-associated clade A1 strains in murine gastrointestinal colonization. Here, parenterally administered piperacillin-tazobactam and ceftriaxone significantly promoted colonization by clade A1 over clade B strains except that ceftriaxone, at the dose used, did not favor the least β-lactam-resistant A1 strain.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00903-22

Reference28 articles.

1. Genomic and SNP Analyses Demonstrate a Distant Separation of the Hospital and Community-Associated Clades of Enterococcus faecium

2. Emergence of Epidemic Multidrug-Resistant Enterococcus faecium from Animal and Commensal Strains

3. Enterococcus faecium PBP5-S/R, the Missing Link between PBP5-S and PBP5-R

4. Impact of Specific pbp5 Mutations on Expression of β-Lactam Resistance in Enterococcus faecium

5. Differential Penicillin-Binding Protein 5 (PBP5) Levels in the Enterococcus faecium Clades with Different Levels of Ampicillin Resistance

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