Enterococcus faecium PBP5-S/R, the Missing Link between PBP5-S and PBP5-R-Reference-Cited by-同舟云学术

Enterococcus faecium PBP5-S/R, the Missing Link between PBP5-S and PBP5-R

Published:2014-09-02 Issue:11 Volume:58 Page:6978-6981
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob. Agents Chemother.

Author:

Pietta Ester,Montealegre Maria Camila,Roh Jung Hyeob,Cocconcelli Pier Sandro,Murray Barbara E.

Abstract

ABSTRACTDuring a study to investigate the evolution of ampicillin resistance inEnterococcus faecium, we observed that a number ofE. faeciumstrains, mainly from the recently described subclade A2, showed PBP5 sequences in between PBP5-S and PBP5-R. These hybrid PBP5-S/R patterns reveal a progression of amino acid changes from the S form to the R form of this protein; however, these changes do not strictly correlate with changes in ampicillin MICs.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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