Virulence of Six Strains of Mycobacterium bovis (BCG) in Mice-Reference-Cited by-同舟云学术

Virulence of Six Strains of Mycobacterium bovis (BCG) in Mice

Published:1973-11 Issue:5 Volume:8 Page:736-742
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Sher Neal A.¹²,Chaparas Sotiros D.¹²,Pearson Jack¹²,Chirigos Michael¹²

Affiliation:

1. Division of Bacterial Products, Bureau of Biologics, Food and Drug Administration, Rockville, Maryland 20852

2. National Cancer Institute, Bethesda, Maryland 20014

Abstract

The abilities of six strains of Mycobacterium bovis strain BCG to replicate in vivo and to cause spleen enlargement in the CDF 1 male mouse were compared. The strains were grown in synthetic medium and harvested soon after complete pellicles were produced on liquid medium. In addition, two freeze-dried commercially available preparations were tested. The comparisons were made on the basis of injecting equal numbers of colony-forming units. Strain differences were marked. The Brazil strain was most effective in stimulating spleen enlargement, and the Japan strain was the least effective. This correlated with the number of colony-forming units isolated from the spleen.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.8.5.736-742.1973

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