Comparison of Strains of BCG I. Antigenic Analysis and Tuberculin Reactivity

Author:

Chaparas Sotiros D.1,Hedrick Sally R.1

Affiliation:

1. Bureau of Biologics, Food and Drug Administration, Rockville, Maryland 20852

Abstract

At least 10 of 11 demonstrable antigens in unheated culture filtrates of 12 vaccine strains of BCG were shared as determined in a reference antigen-antibody immunoelectrophoresis system. Filtrates from each of the BCG strains gave equivalent skin test reactions in homologously and heterologously sensitized guinea pigs. By these immunological parameters, the 12 BCG strains were remarkably similar.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference13 articles.

1. CHAPARAS AND HEDRICK

2. The classification of mycobacteria with the help of different chemical tests;Bonicke R.;Bull. Int Un. Tuberc.,1957

3. The immunology and chemistry of tuberculin. II. Chromatography with Sephadex of the nondialyzable tuberculin active constituents of BCG culture filtrate;Chaparas S. D.;Amer. Rev. Resp. Dis.,1964

4. A reference system for antigens of Mycobacterium tuberculosis;Janicki B. W.;Amer. Rev. Resp. Dis.,1971

5. The acquired resistance to tuberculosis induced by BCG vaccine assayed by a quantitative method on red mice. II. Vaccination effect of BCG strains strongly or moderately virulent for hamsters;Jespersen A.;Acta Tuberc. Pneunol. Scand.,1963

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