The CtrA Regulon of Rhodobacter sphaeroides Favors Adaptation to a Particular Lifestyle

Author:

Hernández-Valle José1,Sanchez-Flores Alejandro2,Poggio Sebastian1,Dreyfus Georges3,Camarena Laura1ORCID

Affiliation:

1. Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico

2. Unidad Universitaria de Secuenciación Masiva y Bioinformática, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Mexico City, Mexico

3. Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico

Abstract

Cell motility in Alphaproteobacteria is frequently controlled by the CckA, ChpT, and CtrA two-component system. Under the growth conditions commonly used in the laboratory, ctrA is transcriptionally inactive in Rhodobacter sphaeroides , and motility depends on the Fla1 flagellar system that was acquired by a horizontal transfer event. Likely, the incorporation of this flagellar system released CtrA from the strong selective pressure of being the main motility regulator, allowing this two-component system to specialize and respond to some specific conditions. Identifying the genes that are directly regulated by CtrA could help us understand the conditions in which the products of this regulon are required. Massive parallel transcriptome sequencing (RNA-seq) revealed that CtrA orchestrates an adaptive response that contributes to the colonization of a particular environmental niche.

Funder

Consejo Nacional de Ciencia y Tecnología

UNAM | Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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