Affiliation:
1. Amrita Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences, AIMS—Edapally, Cochin, Kerala, India
2. Microbial Genetics, Interfaculty Institute for Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen, Tübingen, Germany
Abstract
ABSTRACT
Polymicrobial infections involving
Staphylococcus aureus
exhibit enhanced disease severity and morbidity. We reviewed the nature of polymicrobial interactions between
S. aureus
and other bacterial, fungal, and viral cocolonizers. Microbes that were frequently recovered from the infection site with
S. aureus
are
Haemophilus influenzae
,
Enterococcus faecalis
,
Pseudomonas aeruginosa
,
Streptococcus pneumoniae
,
Corynebacterium
sp.,
Lactobacillus
sp.,
Candida albicans
, and influenza virus. Detailed analyses of several
in vitro
and
in vivo
observations demonstrate that
S. aureus
exhibits cooperative relations with
C. albicans
,
E. faecalis
,
H. influenzae
, and influenza virus and competitive relations with
P. aeruginosa
,
Streptococcus pneumoniae
,
Lactobacillus
sp., and
Corynebacterium
sp. Interactions of both types influence changes in
S. aureus
that alter its characteristics in terms of colony formation, protein expression, pathogenicity, and antibiotic susceptibility.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
116 articles.
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