In VitroActivity of Proveblue (Methylene Blue) on Plasmodium falciparum Strains Resistant to Standard Antimalarial Drugs

Abstract

ABSTRACTThe geometric mean 50% inhibitory concentration (IC50) for Proveblue, a methylene blue complying with the European Pharmacopoeia, was more active on 23P. falciparumstrains than chloroquine, quinine, mefloquine, monodesethylamodiaquine, and lumefantrine. We did not find significant associations between the Proveblue IC50and polymorphisms in thepfcrt,pfmdr1,pfmdr2,pfmrp, andpfnhe-1genes or the copy numbers of thepfmdr1andpfmdr2genes, all of which are involved in antimalarial resistance.