Diagnostic Performance of the HCV Core Antigen Test To Identify Hepatitis C in HIV-Infected Patients: a Systematic Review and Meta-Analysis

Author:

Sepúlveda-Crespo Daniel12,Treviño-Nakoura Ana34,Bellon José M.5,Jiménez-Sousa María A.12,Ryan Pablo26,Martínez Isidoro12,Fernández-Rodríguez Amanda12,Resino Salvador12ORCID

Affiliation:

1. Unidad de Infección Viral e Inmunidad. Centro Nacional de Microbiología – Instituto de Salud Carlos III, Majadahonda, Spain

2. Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain

3. Servicio de Medicina Preventiva y Salud Pública, Hospital Universitario Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain

4. Universidad Nacional de Educación a Distancia (UNED), Madrid, Spain

5. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain

6. Servicio de Medicina Interna, Hospital Universitario Infanta Leonor, Madrid, Spain

Abstract

The standard algorithm for diagnosing hepatitis C virus (HCV) infection has two steps, an HCV antibody test for screening and a nucleic acid amplification test (NAAT) for confirmation. However, the HCV core antigen (HCVcAg) detection assay is an alternative for one-step diagnosis.

Funder

MEC | Instituto de Salud Carlos III

Gilead Sciences

Centro de Investigación Biomédica en Enfermedades Infecciosas

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference50 articles.

1. Hepatitis C

2. World Health Organization. 2022. Hepatitis C. https://www.who.int/news-room/fact-sheets/detail/hepatitis-c.

3. Hepatitis C virus vaccine design: focus on the humoral immune response

4. World Health Organization. 2022. Global health sector strategies: viral hepatitis 2016–2021. http://apps.who.int/gb/ebwha/pdf_files/WHA69/A69_32-en.pdf?ua=1.

5. World Health Organization. 2021. The global health sector strategies on respectively HIV viral hepatitis and sexually transmitted infections 2022–2030. https://www.who.int/publications/i/item/9789240053779.

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