IgG Antibody Response to Toxins A and B in Patients with Clostridium difficile Infection-Reference-Cited by-同舟云学术

IgG Antibody Response to Toxins A and B in Patients with Clostridium difficile Infection

Published:2012-09 Issue:9 Volume:19 Page:1552-1554
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Wullt M.¹,Norén T.²,Ljungh Å.³,Åkerlund T.⁴

Affiliation:

1. Infectious Diseases Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden

2. Department of Infectious Diseases, Örebro University Hospital, Örebro, Sweden

3. Department of Medical Microbiology, Dermatology and Infection, Lund University, Lund, Sweden

4. Department of Analysis and Prevention, Unit for Antibiotics and Infection Control, Swedish Institute for Communicable Disease Control, Solna, Sweden

Abstract

ABSTRACT IgG antibodies against Clostridium difficile toxins A and B were followed in controls and in patients with an initial C. difficile infection (CDI). Of the 50 CDI patients, 38 were cured and 12 developed recurrence. Compared to controls, patients had significantly lower anti-toxin A and B IgGs at inclusion, but the subsequent levels rose slightly regardless of clinical outcome. The results imply that the general serum reactivity against toxins A and B in the population reduces the risk of CDI, which suggests implications for vaccine strategies.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00210-12

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