Novel Biomarkers, Including <i>tcdB</i> PCR Cycle Threshold, for Predicting Recurrent Clostridioides difficile Infection-Reference-Cited by-同舟云学术

Novel Biomarkers, Including tcdB PCR Cycle Threshold, for Predicting Recurrent Clostridioides difficile Infection

Published:2023-04-18 Issue:4 Volume:91 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Madden Gregory R.¹^ORCID,Rigo Isaura¹,Boone Rachel¹,Abhyankar Mayuresh M.¹,Young Mary K.¹,Basener William²,Petri William A.¹³^ORCID

Affiliation:

1. Division of Infectious Diseases & International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA

2. School of Data Science, University of Virginia School of Medicine, Charlottesville, Virginia, USA

3. Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA

Abstract

Traditional clinical models for predicting recurrent Clostridioides difficile infection do not perform well, likely owing to the complex host-pathogen interactions involved. Accurate risk stratification using novel biomarkers could help prevent recurrence by improving underutilization of effective therapies (i.e., fecal transplant, fidaxomicin, bezlotoxumab).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00092-23

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