Affiliation:
1. Department of Microbiology, The University of Texas Southwestern Medical School, Dallas, Texas
Abstract
McClatchy
, J. K. (The University of Texas, Dallas),
and E. D. Rosenblum
. Induction of lactose utilization in
Staphylococcus aureus
. J. Bacteriol.
86:
1211–1215. 1963.—Adaptation to the utilization of lactose by
Staphylococcus aureus
has been compared with that by
Escherichia coli
. Lactose and galactose were found to be efficient inducers of the β-galactosidase and the postulated galactoside-permease of
S. aureus
; the thiogalactosides, active as gratuitous inducers for
E. coli
, were inactive and inhibited induction of staphylococci by lactose and galactose. Mutants lacking β-galactosidase or galactoside-permease, as well as a constitutive mutant for lactose utilization, were isolated. Like that in
E. coli
, the genetic system of staphylococcus seems to consist of two structural genes for the synthesis of the two enzymes and at least one regulatory gene simultaneously controlling the expression of the structural genes. The mutants were grouped by cross-transduction studies in three loci corresponding to the three phenotypes. Mutants of the pleiotropic locus were also isolated.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference15 articles.
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3. The induced (adaptive) biosynthesis of B-galactosidase in Staphylococcus aureus;CREASER E. H.;J. Gen. Microbiol.,1955
4. Direct utilization of maltose by Escherichia coli;DOUDOROFF M., W.;J. Biol. Chem.,1949
5. Serology and transduction in staphylococcal phage;DOWELL C. E.;J. Bacteriol.,1962
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