Affiliation:
1. Department of Microbiology, Upstate Medical Center, State University of New York, Syracuse, New York
Abstract
Marucci, Americo
A. (Upstate Medical Center, Syracuse, N.Y.). Mechanism of action of staphylococcal alpha-hemolysin. II. Analysis of the kinetic curve and inhibition by specific antibody. J. Bacteriol.
86:
1189–1195. 1963.—At least two steps are necessary before the rabbit erythrocyte is lysed by staphylococcal alpha-hemolysin. The first step involves the reaction of alpha-hemolysin with the red cell. The second step, leading to the release of hemoglobin, is an intrinsic reaction of the damaged red cell and takes place without further participation of hemolysin. The speed of this intrinsic reaction is temperature-dependent. Erythrocytes taken from the same rabbit do not vary in their susceptibility to the alpha-hemolysin. From the results of the experiments described herein, a preliminary hypothesis on the mechanism of action of staphylococcal alpha-hemolysin is given.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference10 articles.
1. Observations on antiphage sera. I. "The percentage law;ANDREWES C. H.;Brit. J. Exptl. Pathol.,1933
2. Isolation and composition of staphylococcal alpha toxin;BERNHEIMER A. W.;J. Gen. Microbiol.,1963
3. Immunochemistry of enzymes;CINADER B.;Ann. N. Y. Acad. Sci.,1963
4. ELEK S. D. 1959. Staphylococcus pyogenes and its relation to disease. E. & S. Livingstone Ltd. Edinburgh.
5. The characterization of staphylococcal toxins. I. The electrophoretic migration of the alpha hemolytic, dermonecrotic, lethal and leucocidal activities of crude toxin;KUMAR S.;J. Exptl. Med.,1962
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