Efficacy of Cinoxacin in Urinary Tract Infections

Author:

Panwalker Anand P.1,Giamarellou Helen1,Jackson George G.1

Affiliation:

1. Department of Medicine, University Hospital, Abraham Lincoln School of Medicine, University of Illinois, Chicago, Illinois 60680

Abstract

Cinoxacin, a new synthetic antibacterial agent with in vitro activity against all species of Enterobacteriaceae , was used in the treatment of urinary tract infections in 20 patients. The dose of cinoxacin was 250 mg orally every 6 h for 10 days. The etiological agents were Escherichia coli in fifteen, Klebsiella-Enterobacter in five, Proteus mirabilis in two, and Providencia in one. The minimal inhibitory concentration for these organisms ranged from 2 to 64 μg/ml. Eleven of the 20 patients had renal involvement by defined criteria, whereas the remaining nine were considered to have bladder bacilluria. The initial strain was eradicated during and immediately after treatment in 19 of 20 cases. At 6 weeks, 65% had sterile urine. Bactericidal urine levels of cinoxacin were obtained in all patients. No significant hematological, renal, hepatic, or gastroenterologic toxicity was noted. Cinoxacin appears to be a safe and useful drug in the treatment of urinary tract infections caused by Enterobacteriaceae .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference6 articles.

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2. Lilly Research Laboratories. 1974. Clinical pharmacology of cinoxacin. Information for clinical investigators. Lilly Research Laboratory Indianapolis.

3. Cinoxacin: in vitro antibacterial studies of a new synthetic organic acid;Lumish R. M.;Antimicrob. Agents Chemother.,1975

4. Treatment of pyelonephritis: bacterial, drug and host factors in success or failure among 252 patients;McCabe W. R.;N. Engl. J. Med.,1965

5. Serum versus urinary antimicrobial concentrations and urinary tract infections;Stamey T. A.;N. Engl. J. Med.,1974

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