Affiliation:
1. Department of Medicine, University Hospital, Abraham Lincoln School of Medicine, University of Illinois, Chicago, Illinois 60680
Abstract
Cinoxacin, a new synthetic antibacterial agent with in vitro activity against all species of
Enterobacteriaceae
, was used in the treatment of urinary tract infections in 20 patients. The dose of cinoxacin was 250 mg orally every 6 h for 10 days. The etiological agents were
Escherichia coli
in fifteen,
Klebsiella-Enterobacter
in five,
Proteus mirabilis
in two, and
Providencia
in one. The minimal inhibitory concentration for these organisms ranged from 2 to 64 μg/ml. Eleven of the 20 patients had renal involvement by defined criteria, whereas the remaining nine were considered to have bladder bacilluria. The initial strain was eradicated during and immediately after treatment in 19 of 20 cases. At 6 weeks, 65% had sterile urine. Bactericidal urine levels of cinoxacin were obtained in all patients. No significant hematological, renal, hepatic, or gastroenterologic toxicity was noted. Cinoxacin appears to be a safe and useful drug in the treatment of urinary tract infections caused by
Enterobacteriaceae
.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference6 articles.
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2. Lilly Research Laboratories. 1974. Clinical pharmacology of cinoxacin. Information for clinical investigators. Lilly Research Laboratory Indianapolis.
3. Cinoxacin: in vitro antibacterial studies of a new synthetic organic acid;Lumish R. M.;Antimicrob. Agents Chemother.,1975
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5. Serum versus urinary antimicrobial concentrations and urinary tract infections;Stamey T. A.;N. Engl. J. Med.,1974
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