Affiliation:
1. Department of Medicine, Montefiore Hospital and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213
Abstract
Cinoxacin (compound 64716) is a synthetic organic acid with antibacterial activity against most aerobic gram-negative bacilli. Minimal inhibitory concentrations of cinoxacin (agar-dilution method) were determined for 419 strains.
Escherichia coli
was the most susceptible group of organisms. The majority of
Klebsiella
sp.,
Enterobacter
sp.,
Proteus
sp., and
Serratia marcescens
were inhibited by 8 μg of cinoxacin per ml.
Pseudomonas aeruginosa
and all gram-positive isolates tested were resistant to 64 μg or less of cinoxacin per ml. Zones of inhibition using a 30-μg disk correlated well with agar-dilution minimal inhibitory concentrations (r = −0.9). Cinoxacin was bactericidal when tested with inocula of 5 × 10
6
organisms per ml. Resistance to cinoxacin was readily developed in all three strains tested by serial passage on drug-containing agar. The in vitro properties of this agent were similar to those of nalidixic acid.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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