Rapid Tuberculosis Diagnosis Using Reporter Enzyme Fluorescence-Reference-Cited by-同舟云学术

Rapid Tuberculosis Diagnosis Using Reporter Enzyme Fluorescence

Published:2019-12 Issue:12 Volume:57 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Sule Preeti¹,Tilvawala Ronak¹,Mustapha Toriq¹,Hassounah Hany¹,Noormohamed Aneesa¹,Kundu Suprateek²,Graviss Edward A.³,Walkup Grant K.⁴,Kong Ying⁵,Cirillo Jeffrey D.¹^ORCID

Affiliation:

1. Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, Texas, USA

2. Department of Biostatistics & Bioinformatics, Emory University, Atlanta, Georgia, USA

3. Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, Texas, USA

4. Agios Pharmaceuticals, Cambridge, Massachusetts, USA

5. Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA

Abstract

Tuberculosis is the most frequent cause of death in humans from a single infectious agent. Due to low numbers of bacteria present in sputum during early infection, diagnosis does not usually occur until >3 to 4 months after symptoms develop. We created a new more sensitive diagnostic that can be carried out in 10 min with no processing or technical expertise.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Heart, Lung, and Blood Institute

Bill and Melinda Gates Foundation

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01462-19

Reference75 articles.