Age-Dependent Reduction in Neutralization against Alpha and Beta Variants of BNT162b2 SARS-CoV-2 Vaccine-Induced Immunity-Reference-Cited by-同舟云学术

Age-Dependent Reduction in Neutralization against Alpha and Beta Variants of BNT162b2 SARS-CoV-2 Vaccine-Induced Immunity

Published:2021-12-22 Issue:3 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Kawasuji Hitoshi¹,Morinaga Yoshitomo²³^ORCID,Tani Hideki²⁴^ORCID,Saga Yumiko²⁴,Kaneda Makito¹,Murai Yushi¹,Ueno Akitoshi¹,Miyajima Yuki¹,Fukui Yasutaka¹,Nagaoka Kentaro¹,Ono Chikako⁵⁶,Matsuura Yoshiharu⁵⁶,Niimi Hideki³⁷,Yamamoto Yoshihiro¹³

Affiliation:

1. Department of Clinical Infectious Diseases, Toyama University Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan

2. Department of Microbiology, Toyama University Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan

3. Clinical and Research Center for Infectious Diseases, Toyama University Hospital, Toyama, Japan

4. Department of Virology, Toyama Institute of Health, Toyama, Japan

5. Laboratory of Virus Control, Center for Infectious Disease Education and Research (CiDER), Osaka University, Osaka, Japan

6. Laboratory of Virus Control, Research Institute for Microbial Diseases (RIMD), Osaka University, Osaka, Japan

7. Department of Clinical Laboratory and Molecular Pathology, Toyama University Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan

Abstract

Since mRNA vaccines utilize wild-type SARS-CoV-2 spike protein as an antigen, there are potential concerns about acquiring immunity to variants of this virus. The neutralizing activity in BNT162b2-vaccinated individuals was higher against the wild-type virus than against its variants; this effect was more apparent in older age groups.

Funder

University of Toyama

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.00561-21

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