The Short-Chain Fatty Acids Propionate and Butyrate Augment Adherent-Invasive Escherichia coli Virulence but Repress Inflammation in a Human Intestinal Enteroid Model of Infection-Reference-Cited by-同舟云学术

The Short-Chain Fatty Acids Propionate and Butyrate Augment Adherent-Invasive Escherichia coli Virulence but Repress Inflammation in a Human Intestinal Enteroid Model of Infection

Published:2021-10-31 Issue:2 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Pace Fernanda¹²,Rudolph Sara E.³,Chen Ying³,Bao Bin²⁴,Kaplan David L.³,Watnick Paula I.¹²^ORCID

Affiliation:

1. Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, USA

2. Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA

3. Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, USA

4. Division of Gastroenterology, Hepatology and Nutrition, Boston Children’s Hospital, Boston, Massachusetts, USA

Abstract

The human terminal ileum and colon are colonized by a community of microbes known as the microbiota. Short-chain fatty acids (SCFAs) excreted by bacterial members of the microbiota define the intestinal environment.

Funder

Boston Children's Hospital

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.01369-21

Reference43 articles.

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2. Short chain fatty acids in human large intestine, portal, hepatic and venous blood.

3. Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases

4. The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinogenesis

5. Interplay between food and gut microbiota in health and disease

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