Serological Testing Reveals the Hidden COVID-19 Burden among Health Care Workers Experiencing a SARS-CoV-2 Nosocomial Outbreak-Reference-Cited by-同舟云学术

Serological Testing Reveals the Hidden COVID-19 Burden among Health Care Workers Experiencing a SARS-CoV-2 Nosocomial Outbreak

Published:2021-10-31 Issue:2 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Nakagama Yu¹²^ORCID,Komase Yuko³,Candray Katherine¹²,Nakagama Sachie¹²,Sano Fumiaki⁴,Tsuchida Tomoya⁵,Kunishima Hiroyuki⁶,Imai Takumi⁷,Shintani Ayumi⁷,Nitahara Yuko¹²^ORCID,Kaku Natsuko¹²,Kido Yasutoshi¹²^ORCID

Affiliation:

1. Department of Parasitology, Graduate School of Medicine, Osaka City University, Osaka, Japan

2. Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka City University, Osaka, Japan

3. Department of Respiratory Internal Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital, Yokohama, Japan

4. Department of Hematology and Oncology, St. Marianna University School of Medicine, Yokohama City Seibu Hospital, Yokohama, Japan

5. Division of General Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan

6. Department of Infectious Diseases, St. Marianna University School of Medicine, Kawasaki, Japan

7. Department of Medical Statistics, Graduate School of Medicine, Osaka City University, Osaka, Japan

Abstract

We describe the results of testing frontline health care workers, from a hospital in Japan that had experienced a COVID-19 outbreak, for SARS-CoV-2-specific antibodies. Antibody testing revealed that a surprising 42% of overlooked COVID-19 diagnoses occurred when case detection relied solely on PCR-based viral detection.

Funder

Japan Agency for Medical Research and Development

Special Reserves Fund for COVID-19, Osaka City University

COVID-19 Private Fund, Shinya Yamanaka Laboratory

BIKEN Taniguchi Scholarship

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.01082-21

Reference20 articles.