Loss of RND-Type Multidrug Efflux Pumps Triggers Iron Starvation and Lipid A Modifications in Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Loss of RND-Type Multidrug Efflux Pumps Triggers Iron Starvation and Lipid A Modifications in Pseudomonas aeruginosa

Published:2021-09-17 Issue:10 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Adamiak Justyna W.¹,Jhawar Varsha¹,Bonifay Vincent¹,Chandler Courtney E.²,Leus Inga V.¹,Ernst Robert K.²^ORCID,Schweizer Herbert P.³^ORCID,Zgurskaya Helen I.¹^ORCID

Affiliation:

1. University of Oklahoma, Department of Chemistry and Biochemistry, Norman, Oklahoma, USA

2. University of Maryland, Baltimore, Department of Microbial Pathogenesis, Baltimore, Maryland, USA

3. Northern Arizona University, Pathogen and Microbiome Institute, Flagstaff, Arizona, USA

Abstract

Transporters belonging to the r esistance- n odulation- d ivision (RND) superfamily of proteins are invariably present in the genomes of Gram-negative bacteria and are largely responsible for the intrinsic antibiotic resistance of these organisms. The numbers of genes encoding RND transporters per genome vary from 1 to 16 and correlate with the environmental versatilities of bacterial species. Pseudomonas aeruginosa strain PAO1, a ubiquitous nosocomial pathogen, possesses 12 RND pumps, which are implicated in the development of clinical multidrug resistance and known to contribute to virulence, quorum sensing, and many other physiological functions.

Funder

DOD | Defense Threat Reduction Agency

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00592-21

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