Nonlethal Molecular Nanomachines Potentiate Antibiotic Activity Against Gram-Negative Bacteria by Increasing Cell Permeability and Attenuating Efflux

Author:

Santos Ana L.12,Liu Dongdong1ORCID,van Venrooy Alexis1,Beckham Jacob L.1,Oliver Antonio234,Tegos George P.5,Tour James M.1678ORCID

Affiliation:

1. Department of Chemistry, Rice University, Houston, Texas 77005, United States

2. IdISBA - Fundación de Investigación Sanitaria de las Islas Baleares, 07120 Palma, Spain

3. Servicio de Microbiologia, Hospital Universitari Son Espases, 07120 Palma, Spain

4. Centro de Investigación Biomédica en Red, Enfermedades Infecciosas (CIBERINFEC), Av. Monforte de Lemos 3-5, 28029 Madrid, Spain

5. Office of Research, Faxton St. Luke’s Healthcare, Mohawk Valley Health System, 1676 Sunset Avenue, Utica, New York 13502, United States

6. Smalley-Curl Institute, Rice University, Houston, Texas 77005, United States

7. Department of Materials Science and NanoEngineering, Rice University, Houston, Texas 77005, United States

8. NanoCarbon Center and Rice Advanced Materials Institute, Rice University, Houston, Texas 77005, United States

Funder

Welch Foundation

Division of Graduate Education

H2020 Marie Sklodowska-Curie Actions

Army Research Laboratory

The Discovery Institute

Publisher

American Chemical Society (ACS)

Reference68 articles.

1. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

2. O’Neill, J. Antimicrobial Resistance: Tackling a Crisis for the Health and Wealth of Nations; Wellcome Trust & HM Government: London, 2014. https://amr-review.org/sites/default/files/160525_Finalpaper_withcover.pdf (accessed 9 Jan 2024).

3. The Antibacterial Research and Development Pipeline Needs Urgent Solutions

4. Antibiotics: past, present and future

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