In Vivo Fitness Adaptations of Colistin-Resistant Acinetobacter baumannii Isolates to Oxidative Stress-Reference-Cited by-同舟云学术

In Vivo Fitness Adaptations of Colistin-Resistant Acinetobacter baumannii Isolates to Oxidative Stress

Published:2017-03 Issue:3 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Jones Crystal L.¹,Singh Shweta S.¹,Alamneh Yonas¹,Casella Leila G.²,Ernst Robert K.²,Lesho Emil P.³,Waterman Paige E.³,Zurawski Daniel V.¹

Affiliation:

1. Wound Infections Department, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA

2. Department of Microbial Pathogenesis, University of Maryland School of Dentistry, Baltimore, Maryland, USA

3. Multidrug-resistant Organism Repository and Surveillance Network, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA

Abstract

ABSTRACT The loss of fitness in colistin-resistant (CR) Acinetobacter baumannii was investigated using longitudinal isolates from the same patient. Early CR isolates were outcompeted by late CR isolates for growth in broth and survival in the lungs of mice. Fitness loss was associated with an increased susceptibility to oxidative stress since early CR strains had reduced in vitro survival in the presence of hydrogen peroxide and decreased catalase activity compared to that of late CR and colistin-susceptible (CS) strains.

Funder

MIDRP

DMRDP

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00598-16

Reference15 articles.

1. Phosphoethanolamine Modification of Lipid A in Colistin-Resistant Variants of Acinetobacter baumannii Mediated by the pmrAB Two-Component Regulatory System

2. ThepmrCABOperon Mediates Polymyxin Resistance inAcinetobacter baumanniiATCC 17978 and Clinical Isolates through Phosphoethanolamine Modification of Lipid A