Impaired Virulence and Fitness of a Colistin-Resistant Clinical Isolate of Acinetobacter baumannii in a Rat Model of Pneumonia

Abstract

ABSTRACTWe compared the fitness and lung pathogenicity of two isogenic clinical isolates ofAcinetobacter baumannii, one resistant (ABCR) and the other susceptible (ABCS) to colistin.In vitro, ABCR exhibited slower growth kinetics than ABCS. In a rat model of pneumonia, ABCR was associated with less pronounced signs of infection (lung bacterial count, systemic dissemination, and lung damage) and a better outcome (ABCR and ABCS mortality rates, 20 and 50%, respectively [P= 0.03]).