Benznidazole in Cerebrospinal Fluid: a Case Series of Chagas Disease Meningoencephalitis in HIV-Positive Patients

Author:

Fernández Marisa L.12ORCID,Marson María E.3,Mastrantonio Guido E.3,Corti Marcelo A.1,Fleitas Ulises3,Lloveras Susana C.1,Lista Nicolas1,Priarone Maria M.1,Domínguez Cecilia1,Garcia-Bournissen Facundo4

Affiliation:

1. Hospital de Infecciosas FJ Muñiz, Buenos Aires, Argentina

2. Instituto Nacional de Parasitología Dr M Fatala Chaben, ANLIS Dr C Malbran, Ministerio de Salud, Buenos Aires, Argentina

3. UPL (CICpBA-UNLP), Área Toxicología, Facultad de Ciencias Exactas/UNLP/CONICET, La Plata, Argentina

4. Division of Paediatric Clinical Pharmacology, Department of Paediatrics, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada

Abstract

Chagas disease reactivation in HIV-positive people is an opportunistic infection with 79 to 100% mortality. It commonly involves the central nervous system (CNS).

Funder

Fundación Bunge y Born

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference24 articles.

1. Reactivation of Chagas disease with central nervous system involvement in HIV-infected patients in Argentina, 1992–2007

2. Panel on Opportunistic Infections in HIV-Infected Adults and Adolescents. 2020. Guidelines for the prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from the Centers for Disease Control and Prevention the National Institutes of Health and the HIV Medicine Association of the Infectious Diseases Society of America. NIH Bethesda MD. http://aidsinfo.nih.gov/contentfiles/lvguidelines/adult_oi.pdf. Accessed 6 September 2020.

3. Reactivation of Chagas Disease (American trypanosomiasis) with brain involvement, in HIV-AIDS patients in Argentina;Sztokhamer D;Actualiz SIDA,2010

4. Co-infection Trypanosoma cruzi/HIV: systematic review (1980 - 2010)

5. Pathology of Patients with Chagas' Disease and Acquired Immunodeficiency Syndrome

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