Affiliation:
1. Department of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada
2. Canadian Bovine Mastitis and Milk Quality Research Network, Saint-Hyacinthe, Quebec, Canada
Abstract
Staphylococcus aureus
is a major cause of bovine intramammary infections, leading to significant economic losses to dairy industry in Canada and worldwide. There is a lack of knowledge regarding genetic diversity, the presence of antimicrobial resistance (AMR), and virulence genes for
S. aureus
isolated from bovine milk in Canada. Based on whole-genome sequencing and genomic analysis, we have determined the phylogeny and diversity of
S. aureus
in bovine milk and concluded that it had a large accessory genome, limited distribution of AMR genes, variable VF gene profiles and sequence types (ST), and clonal complex (CC)-specific pathogenic potentials. Comprehensive information on the population structure, as well as the virulence and resistance characteristics of
S. aureus
from bovine milk, will allow for source attribution, risk assessment, and improved therapeutic approaches in cattle.
Funder
Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada
Publisher
American Society for Microbiology
Subject
Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology
Cited by
40 articles.
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