Redirected Stress Responses in a Genome-Minimized ‘midi Bacillus ’ Strain with Enhanced Capacity for Protein Secretion

Author:

Aguilar Suárez Rocío1ORCID,Antelo-Varela Minia2,Maaß Sandra2ORCID,Neef Jolanda1,Becher Dörte2,van Dijl Jan Maarten1ORCID

Affiliation:

1. University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

2. University of Greifswald, Institute of Microbiology, Department of Microbial Proteomics, Greifswald, Germany

Abstract

Our present study showcases a genome-minimized nonpathogenic bacterium, the so-called midi Bacillus , as a chassis for the development of future industrial strains that serve in the production of high-value difficult-to-produce proteins. In particular, we explain how midi Bacillus , which lacks about one-third of the original genome, effectively secretes a protein of the major human pathogen Staphylococcus aureus that cannot be produced by the parental Bacillus subtilis strain.

Funder

Horizon 2020 program of the European Union

Consejo Nacional de Ciencia y Tecnología

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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